The syntagm Smart Sustainable Development is addressing to the holistic development through the concepts linked with the eco-bio-economy, innovation and quality. The syntagm Integrated Smart Sustainable Development is launched in order to stimulate the interrelation between concepts as eco-economy, bio-economy, economy, biology, biodiversity, ecology, green quality, together with new approaches as eco-bio-economy, agrifood green power, international diplomacy, global economy, sustainable development. Having the target to ensure an integrated sustainable development of the environment, business, communities and economic welfare, new factors to address to this concept would be to integrate the principles related to quality, innovation, total quality management, continuous improvement, excellence in business and organizational excellence, green quality, but also to promote global policies and action plans with active measures to an integrated environmental health, of the biodiversity, for a smart sustainable development in all life areas.